Whats the process for you?, throw caution to the wind, follow traditional designs, don't even bother?. My biggest problem is I've been so manipulated and ingrained by the iconic ones that if it starts to deviate "it just looks wrong". If you start to deviate from a L.P or Strat it starts to look suspiciously like a PRS. Just random thoughts here, one half of me says just do something outlandish just so its not painfully derivative and the other says be more reserved and don't worry about it. It will never be original anyway.